A systematic review of intraoperative radiotherapy in early stage breast cancer
Cuncins-Hearn A, Saunders C, Walsh D, Borg M, Buckingham J, Frizelle F, Maddern G
Record ID 32002000918
English
Authors' objectives:
The objective of this review was to assess the safety and efficacy of intraoperative radiotherapy (IORT) in comparison with the current standard treatment for early breast cancer of breast conserving surgery with postoperative radiotherapy (BCT).
Authors' results and conclusions:
Studies that examined the use of IORT in early breast cancer were limited in number. Only eight unique studies of IORT in early breast cancer could be identified, one was a randomised controlled trial of 70 patients, one a concurrently controlled study and the remainder were case series providing Level IV evidence. In terms of safety, the IORT studies reported only minor postoperative complications that typically resolved within a few months after surgery. In terms of efficacy, short-term follow-up results from the eight IORT studies were similar to breast conserving therapy in terms of local recurrence, disease-free and overall survival but the immaturity of the current evidence base made any definitive assessment of its efficacy tenuous at best.
Authors' recommendations:
Studies that examined the use of IORT in early breast cancer were limited in number. Only eight unique studies of IORT in early breast cancer could be identified, one was a randomised controlled trial of 70 patients, one a concurrently controlled study and the remainder were case series providing Level IV evidence. In terms of safety, the IORT studies reported only minor postoperative complications that typically resolved within a few months after surgery. In terms of efficacy, short-term follow-up results from the eight IORT studies were similar to breast conserving therapy in terms of local recurrence, disease-free and overall survival but the immaturity of the current evidence base made any definitive assessment of its efficacy tenuous at best.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://www.surgeons.org/asernip-s/
Year Published:
2002
URL for published report:
n/a
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Radiotherapy
- Breast Neoplasms
- Radiotherapy, Adjuvant
Contact
Organisation Name:
Australian Safety and Efficacy Register of New Interventional Procedures-Surgical
Contact Address:
ASERNIP-S 24 King William Street, Kent Town SA 5067 Australia Tel: +61 8 8219 0900
Contact Name:
racs.asernip@surgeons.org
Contact Email:
racs.asernip@surgeons.org
Copyright:
Australian Safety and Efficacy Register of New Interventional Procedures - Surgical
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