The effectiveness of infliximab and etanercept for the treatment of rheumatoid arthritis: a systematic review and economic evaluation

Jobanputra P, Barton P, Bryan S, Burls A,
Record ID 32002000903
Authors' objectives:

This report reviews the evidence for the clinical effectiveness and cost-effectiveness of etanercept and infliximab, agents that inhibit tumour necrosis factor alpha (TNFa) when used in the treatment of rheumatoid arthritis (RA) in adults and referred to as anti-TNFs.

Authors' recommendations: Further research and development of economic models is necessary to reflect clinical practice more accurately. Future models need to include other aspects of RA, such as disease complications, to improve current models. Comparative studies of anti-TNF agents and other DMARDs (new and old) should be carried out, as only one study included in this review compared anti-TNF directly with another DMARD. This showed equivalent efficacy. Such direct comparisons have a potential for informing practice, especially where therapeutic choices that take cost into account are to be made. Studies of the quality of life of RA patients in the long term and the impact of DMARDs and other interventions on quality of life are needed. Also needed are studies of the impact of DMARDs on joint replacement, and other disease and drug-related morbidity, and on mortality.
Authors' methods: Systematic review
Project Status: Completed
URL for project:
Year Published: 2002
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Costs and Cost Analysis
  • Tumor Necrosis Factor-alpha
  • Arthritis, Rheumatoid
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
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Contact Email:
Copyright: 2009 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.