Authors' objectives: CADTH is undertaking a project on intraocular lens (IOL) implantation for infants with aphakia. Aphakia is the absence of the lens of the eye, due to surgical removal, a perforating wound or ulcer, or congenital anomaly. Interventions for optical correction of aphakia in children include aphakic glasses or contact lenses and primary or secondary IOL implantation. However, the optimal timing of primary IOL implantation in pediatric aphakic patients is unclear and remains a challenge for ophthalmologists. Intraocular lens implantation for infants younger than 12 months old would reduce the need for compliance with the alternative external optical devices and associated ongoing costs for parents and caregivers; however, concerns about selecting the appropriate lens power and long-term effectiveness remain. This systematic review will address the effectiveness and safety of IOL implantation in infants younger than 12 months old. In addition, the economic literature will be reviewed to evaluate whether this intervention is cost-effective.

Project Status: Completed

URL for project: https://cadth.ca/intraocular-lens-implantation-infants-aphakia-systematic-review-clinical-effectiveness-and-cost

URL for protocol: https://www.cadth.ca/sites/default/files/pdf/htis/2021/RE0036-IOL-for-Infants-with-Aphakia-Protocol-v5.2.pdf

Year Published: 2022

URL for published report: https://www.cadth.ca/sites/default/files/pdf/htis/2022/RE0036%20Intraocular%20lens%20infants%20v.7.0-final.pdf

URL for additional information: https://www.cadth.ca/intraocular-lenses-infants-aphakia

English language abstract: An English language summary is available

Publication Type: Mini HTA

Country: Canada

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: <p>Canadian Agency for Drugs and Technologies in Health (CADTH)</p>