Drugs for the management of rheumatoid arthritis: clinical evaluation

Wells GA, Smith C, Hossain A, Karsh J, Singh J, Hazlewood G, Tugwell P
Record ID 32018002213
English
Original Title: Drugs for the management of rheumatoid arthritis
Authors' objectives: The objective of this review is to assess the benefits and harms of drugs used in adult patients with moderate to severe RA in whom treatment with MTX has failed or who are intolerant to MTX. The research question was: What is the comparative clinical efficacy and safety of csDMARD therapies (alone or in combination), biologics (including biosimilars), and tsDMARDs in adult patients with moderate to severe RA in whom treatment with MTX has failed or who are intolerant to MTX?
Details
Project Status: Completed
URL for project: https://cadth.ca/drugs-management-rheumatoid-arthritis
URL for protocol: https://cadth.ca/drugs-management-rheumatoid-arthritis-clinical-evaluation-project-protocol
Year Published: 2018
URL for published report: https://cadth.ca/sites/default/files/pdf/HT0010_RA_Report.pdf
URL for additional information: https://cadth.ca/drugs-management-rheumatoid-arthritis
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Canada
Pubmed ID: 30325625
MeSH Terms
  • Arthritis, Rheumatoid
  • Methotrexate
  • Drug Therapy, Combination
  • Antirheumatic Agents
  • Biological Products
  • Biosimilar Pharmaceuticals
Keywords
  • Rheumatoid arthritis
  • Drug therapy
  • Methotrexate
  • Biologicals
  • DMARDs
Contact
Organisation Name: Canadian Agency for Drugs and Technologies in Health
Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;
Contact Name: requests@cadth.ca
Contact Email: requests@cadth.ca
Copyright: <p>Canadian Agency for Drugs and Technologies in Health (CADTH)</p>
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.