Authors' objectives: Dual antiplatelet therapy (DAPT), the combination of a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) with acetylsalicylic acid (ASA), is routinely given following percutaneous coronary intervention (PCI) with stenting. This therapy aims to prevent stent thrombosis and other major cardiovascular adverse events associated with PCI. The choice of DAPT duration remains uncertain, although new evidence on the effect of longer treatment duration has recently become available. Selecting the treatment duration is an important decision in order to balance the benefits and harms of DAPT following PCI. This project aims to summarize the evidence currently available on the comparative clinical effect of using shorter (6 to 12 months) versus longer (12 to 30 months) DAPT following PCI. Results from this project will inform reimbursement policies as well as clinical decisions on the use of P2Y12 inhibitors in patients who recently underwent a PCI.

Project Status: Completed

URL for project: https://cadth.ca/dual-antiplatelet-therapy-following-percutaneous-coronary-intervention-review-clinical-impact

Year Published: 2017

URL for published report: https://cadth.ca/sites/default/files/pdf/HT0001_DAPT_Post_PCI_.pdf

English language abstract: An English language summary is available

Publication Type: Rapid Review

Country: Canada

Pubmed ID: 30299644

Organisation Name: Canadian Agency for Drugs and Technologies in Health

Contact Address: 600-865 Carling Avenue, Ottawa, ON K1S 5S8 Canada. Tel: +1 613 226 2553; Fax: +1 613 226 5392;

Contact Name: requests@cadth.ca

Contact Email: requests@cadth.ca

Copyright: <p>Canadian Agency for Drugs and Technologies in Health (CADTH)</p>