[Autologous stem cell transplantation for multiple sclerosis : rapid scoping review]

Kirkehei I, Hafstad E
Record ID 32018001661
Original Title: Autolog stamcelletransplantasjon ved multippel sklerose : forenklet metodevurdering - kartlegging
Authors' objectives: The Norwegian Instiute of Public Health was commissioned by The Ordering forum for The National System for Managed Introduction of New Health Technologies within the Specialist Health Service in Norway to identify and map ongoing and published randomized controlled trials on the effect of autologous stem cell transplantation for the treatment of multiple sclerosis.
Authors' results and conclusions: We identified five studies on hematopoietic stem cell transplantation (HSCT). One of the studies, MIST, is completed and published. The remaining studies are ongoing, so far with no reported results. We identified ten studies on mesenchymal stem cell transplantation (MSCT). Seven studies are completed, of which five have reported results. Three studies are ongoing, so far with no reported results. We present links to study registries and references to available publications with study results.
Authors' methods: We performed a systematic literature search, identifying studies published as of 2014. We screened and sorted the studies in tables, categorized by transplantation type and study name. The study authors’ conclusions were cited. We did not perform a critical appraisal of the studies’ methodological quality, nor did we analyze the results.
Project Status: Completed
Year Published: 2021
English language abstract: An English language summary is available
Publication Type: Other
Country: Norway
MeSH Terms
  • Multiple Sclerosis
  • Stem Cell Transplantation
  • Transplantation, Autologous
  • Hematopoietic Stem Cell Transplantation
  • Mesenchymal Stem Cell Transplantation
Organisation Name: Norwegian Institute of Public Health
Contact Address: P.O. Box 222 Skoyen, N-0123, Oslo
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.