Percutaneous left ventricular assist devices: micro-axial flow pumps: systematic review
Jeindl R, Goetz G
Record ID 32018001654
Authors' objectives: Myocardial infarction with failure of the left ventricle can cause cardiogenic shock, which is associated with a high mortality. Percutaneous coronary interventions are minimally invasive procedures for revascularisation. Temporary mechanical circulatory support may be considered for both indications. Mechanical circulatory support can be provided by micro-axial percutaneous left ventricular assist devices (pLVAD). This report updates the evidence synthesis published by Health Quality Ontario in 2017.
Authors' results and conclusions: The overall quality of the evidence for effectiveness and safety was rated as very low (GRADE rating). None of the RCTs demonstrated a statistically significant reduction in mortality in favour of the technology. For both indications, the evidence suggested improved haemodynamics with the technology. However, a statistically significant difference in bleeding to the detriment of the technology was shown.
Authors' recomendations: Given the available evidence and potential risks, results from ongoing studies should be awaited. The inclusion in the Austrian benefit catalogue is currently not recommended.
Authors' methods: In total, the updated evidence synthesis included seven studies (4 RCTs and 3 registry studies).
Project Status: Completed
Year Published: 2021
URL for published report: https://eprints.aihta.at/1323/1/DSD_124.pdf
URL for additional information: https://eprints.aihta.at/1323/
English language abstract: An English language summary is available
Publication Type: Full HTA
- Ventricular Dysfunction, Left
- Ventricular Function, Left
- Shock, Cardiogenic
- Percutaneous Coronary Intervention
- Heart Failure
- Heart-Assist Devices
- Left ventricular assist device
- cardiogenic shock
- percutaneous coronary intervention
- micro-axial flow pump
- mechanical circulatory support
Organisation Name: Austrian Institute for Health Technology Assessment
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Copyright: HTA Austria - AIHTA GmbH
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