Percutaneous left ventricular assist devices: micro-axial flow pumps: systematic review

Jeindl R, Goetz G
Record ID 32018001654
English
Authors' objectives: Myocardial infarction with failure of the left ventricle can cause cardiogenic shock, which is associated with a high mortality. Percutaneous coronary interventions are minimally invasive procedures for revascularisation. Temporary mechanical circulatory support may be considered for both indications. Mechanical circulatory support can be provided by micro-axial percutaneous left ventricular assist devices (pLVAD). This report updates the evidence synthesis published by Health Quality Ontario in 2017.
Authors' results and conclusions: The overall quality of the evidence for effectiveness and safety was rated as very low (GRADE rating). None of the RCTs demonstrated a statistically significant reduction in mortality in favour of the technology. For both indications, the evidence suggested improved haemodynamics with the technology. However, a statistically significant difference in bleeding to the detriment of the technology was shown.
Authors' recommendations: Given the available evidence and potential risks, results from ongoing studies should be awaited. The inclusion in the Austrian benefit catalogue is currently not recommended.
Authors' methods: In total, the updated evidence synthesis included seven studies (4 RCTs and 3 registry studies).
Details
Project Status: Completed
URL for project: https://aihta.at/page/bewertung-medizinischer-einzelleistungen-mel-2020/en
Year Published: 2021
URL for published report: https://eprints.aihta.at/1323/1/DSD_124.pdf
URL for additional information: https://eprints.aihta.at/1323/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Ventricular Dysfunction, Left
  • Ventricular Function, Left
  • Shock, Cardiogenic
  • Percutaneous Coronary Intervention
  • Heart Failure
  • Heart-Assist Devices
Keywords
  • Left ventricular assist device
  • cardiogenic shock
  • percutaneous coronary intervention
  • micro-axial flow pump
  • mechanical circulatory support
Contact
Organisation Name: Austrian Institute for Health Technology Assessment
Contact Address: Garnisongasse 7/20, A-1090 Vienna, Austria
Contact Name: office@aihta.at
Contact Email: office@aihta.at
Copyright: HTA Austria - AIHTA GmbH
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.