[Intra-arterial chemotherapy for retinoblastoma]
Donato M, Pichon-Riviere A, Alcaraz A , Augustovski F, García Martí S, Bardach A, Ciapponi A.
Record ID 32018001588
Spanish
Original Title:
Quimioterapia intraarterial en retinoblastoma
Authors' recommendations:
No studies directly comparing intra-arterial chemotherapy with other treatment options for retinoblastoma were found.
Moderate-quality evidence from systematic reviews of observational studies suggests that intra-arterial chemotherapy, mainly as first line treatment and with melphalan alone or in combination with carboplatin and/or topotecan, has an adequate rate of success and would prevent eye enucleation or disease progression in children population with retinoblastoma regardless of the disease severity. As for globe salvage, intra-arterial chemotherapy also had good results, especially in those high-risk patients classified as International Classification of Retinoblastoma Group D. Severe procedure-related complications have been reported, such as oculomotor nerve palsy, retinal detachment, neutropenia and fever, however they rarely occurred.
The latest expert consensus, clinical practice guidelines and international protocols of high-income countries, mention this procedure for the assessed indication. Among the coverage policies surveyed, only Uruguay and the United Kingdom cover the procedure for the assessed indication. No economic assessments were found for Argentina.
Details
Project Status:
Completed
Year Published:
2020
URL for published report:
https://www.iecs.org.ar/home-ets/
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Argentina
MeSH Terms
- Retinoblastoma
- Injections, Intra-Arterial
- Retinal Neoplasms
- Antineoplastic Agents
Contact
Organisation Name:
Institute for Clinical Effectiveness and Health Policy
Contact Address:
Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name:
info@iecs.org.ar
Contact Email:
info@iecs.org.ar
Copyright:
Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.