[FilmArray® in Acute Respiratory Infections and Sepsis]

González L, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A.
Record ID 32018001504
Original Title: FilmArray® en infecciones respiratorias agudas y sepsis
Authors' recommendations: CONCLUSIONS Moderate-quality evidence suggests that the FilmArray® system used to diagnose the etiology of acute respiratory infections and sepsis is highly sensitive and specific in detecting organisms and mechanisms of antibiotic resistance included in the panel OR for which it was designed. Low-quality evidence suggests that in patients with suspected sepsis and positive blood cultures its use would not translate into clinical benefits such as mortality or for the health system. In patients with respiratory infections, low-quality evidence shows contradicting results in terms of its potential benefit in reducing the length of hospital stay or rate of antibiotic prescription. Different clinical practice guidelines and coverage policies surveyed do not mention the multiplex PCR panel (FilmArray®) among the diagnostic studies for these conditions. However, they do consider the use of simple and specific PCR for individual microorganisms. No cost-effectiveness or budget impact studies have been found in Latin America. The econonomic evaluation found concludes that its use to diagnose influenza virus infections in children assessed at the emergency department would not be cost-effective.
Project Status: Completed
Year Published: 2018
URL for published report: https://www.iecs.org.ar/home-ets/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Bacterial Infections
  • Respiratory Tract Infections
  • Sepsis
  • Virus Diseases
  • Real-Time Polymerase Chain Reaction
  • Diagnosis, Differential
  • Molecular Diagnostic Techniques
  • Gram-Negative Bacterial Infections
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.