[Procalcitonin-guided antibiotic therapy for acute infections]

Alfie V, Bardach A, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Ciapponi A.
Record ID 32018001476
Original Title: Procalcitonina como guía para el tratamiento antibiótico de infecciones agudas
Authors' recomendations: CONCLUSIONS Moderate-quality evidence suggests that in adult patients with acute infections who require hospitalization at Intensive Care Units, the use of procalcitonin levels as guidance to discontinue antibiotic therapy, would be associated with lower short-term mortality. This evidence also suggests that the use of procalcitonin levels as guidance at any stage of antibiotic therapy in these patients is associated with shorter treatments, without an increased number of therapeutic failures. High-quality evidence shows that in the pediatric population, the use of procalcitonin-guided antibiotic regimens in neonatal sepsis and airway tract infections requiring hospitalization, was associated with shorter treatments with no increased antibiotic failure rate compared with patients who received standard-of-care antibiotic regimens. The public health sponsors consulted do not mention or do not cover this technology. Most United States private health sponsor consulted do not cover this technology. Half of the clinical practice guidelines reviewed recommends the use of procalcitonin levels as guidance for antibiotic therapy.
Project Status: Completed
Year Published: 2018
URL for published report: https://www.iecs.org.ar/home-ets/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Bacterial Infections
  • Biomarkers
  • Antibiotic Prophylaxis
  • Antimicrobial Stewardship
  • Procalcitonin
  • Respiratory Tract Infections
  • Anti-Bacterial Agents
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.