[LDL-Apheresis in familial hypercholesterolemia and hypertriglyceridemia]

Oubiña M, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A.
Record ID 32018001460
Original Title: Aféresis de lípidos en hipercolesterolemia familiar e hipertrigliceridemia
Authors' recommendations: CONCLUSIONS No evidence has been found assessing the efficacy or effectiveness of LDL-apheresis at mid and long-term in outcomes such as mortality or cardiovascular events. Moderate quality evidence suggests that the use of LDL-apheresis reduces the serum LDL in patients with familial homozygous hypercholesterolemia and refractory familial heterozygous hypercholesterolemia significantly. Low quality evidence suggests that those patients with acute pancreatitis associated to severe hypertriglyceridemia might benefit from this technology. The clinical practice guidelines consulted recommend this technology in patients suffering homozygous familial hypercholesterolemia. They also recommend it in patients who have the heterozygous form taking into account certain levels of lipids and comorbidities. Some guidelines consider its use in patients with acute pancreatitis associated to hypertriglyceridemia. Some health sponsors consulted from high-income countries cover this technology in patients with familial hypercholesterolemia both in its homozygous and heterozygous forms. No cost-effectiveness or budgetary impact studies have been found in Argentina.
Project Status: Completed
Year Published: 2018
URL for published report: https://www.iecs.org.ar/home-ets/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Hyperlipoproteinemia Type II
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Blood Component Removal
  • Triglycerides
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.