[PET/CT scan for solitary pulmonary nodule and non-small cell lung cancer]

Gonzalez L, Pichon-Riviere A, Augustovski F, García Martí S, Alcaraz A, Bardach A, Ciapponi A
Record ID 32018001459
Original Title: PET/TC en nódulo pulmonar solitario y cáncer de pulmón no células pequeñas
Authors' recommendations: CONCLUSIONS High quality evidence shows that the use of PET/CT scan to determine the probability of malignancy in solitary pulmonary nodule has an adequate sensitivity (95%), specificity (82%) and area under the curve (0.94), being the results similar to those of magnetic resonance imaging and better than computed tomography scan. There is consensus among the clinical practice guidelines and the sponsors consulted (all of them from high-income countries) in considering its use in individuals with solid solitary nodules larger than 0.8 cm diameter, where a pretest malignancy probability is 5-65 by clinical assessment or validated predictive model. High quality evidence shows that PET/CT scan in metastasis detection at mediastinal lymph node or bone level is similar to magnetic resonance imaging with diffusion, and has higher sensitivity, specificity and area under the curve when compared against computed tomography scan and bone scintigraphy. The recommendations from different international societies mention its use and include it as standard of care in patients with non-small cell lung cancer, mainly in stage III tumors, in order to rule out distant metastasis and assess the potential involvement of mediastinal lymph nodes. In these cases, it may modify staging resulting in a change in treatment management. The coverage policies from developed countries consulted consider its use in this setting.
Project Status: Completed
Year Published: 2018
URL for published report: https://www.iecs.org.ar/home-ets/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Argentina
MeSH Terms
  • Lung Neoplasms
  • Carcinoma, Non-Small-Cell Lung
  • Positron Emission Tomography Computed Tomography
  • Early Detection of Cancer
  • Solitary Pulmonary Nodule
  • Diagnostic Imaging
Organisation Name: Institute for Clinical Effectiveness and Health Policy
Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA
Contact Name: info@iecs.org.ar
Contact Email: info@iecs.org.ar
Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)
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