Authors' recommendations: CONCLUSIONS High-quality evidence shows that endovascular thrombectomy in addition to thrombolytic (tissue plasminogen activator) therapy in patients with ischemic stroke of the cerebral anterior artery system improves the revascularization rates and functional capacity after 90 days if carried out within 6 hours of symptom onset. High-quality evidence shows that the second generation systems (stent retrievers) are better in terms of rates of revascularization than the first generation ones (Penumbra and Merci) and they have the benefit of extending the treatment window 6-12 hours. The clinical practice guidelines and American, British and French health sponsors recommend thrombectomy with stent retriever along with tissue plasminogen activator in patients suffering a stroke with internal carotid artery or anterior cerebral artery (segment M1) obstruction, within six hours of symptom onset; or in patients with contraindications for drug thrombolysis. No cost-effectiveness studies or budget impact analysis have been identified in Argentina or Latin America.

Project Status: Completed

Year Published: 2018

URL for published report: https://www.iecs.org.ar/home-ets/

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Argentina

Organisation Name: Institute for Clinical Effectiveness and Health Policy

Contact Address: Dr. Emilio Ravignani 2024, Buenos Aires - Argentina, C1414 CABA

Contact Name: info@iecs.org.ar

Contact Email: info@iecs.org.ar

Copyright: Institute for Clinical Effectiveness and Health Policy (IECS)