[Guidelines and standards: respiratory multiplex NAAT (8 or more targets)]

Dubé A
Record ID 32018000947
Original Title: Guide et normes: TAAN multiplex respiratoire (8 cibles ou plus)
Authors' objectives: The use of multiplex PCR to detect respiratory viruses is raising certain concerns. It is usually ordered in a hospital setting, where it facilitates the management of patients with respiratory infections, since it helps limit their spread. However, the experts consulted indicated that, in many cases, the information provided by this test does not change patient management. It is against this backdrop that the present tool was developed.
Authors' results and conclusions: RESULTS: For each clinical indication or target population identified, we present results concerning the test’s diagnostic performance and clinical utility, the positions and leanings of the organizations of interest concerning the test, the pathogenic agents to be screened for and the preferred types of specimens, if applicable. Multiplex PCR is recommended in the following clinical situations, only if the results can modify the patient’s treatment or management: In children admitted to intensive care or at risk for complications in the presence of community-acquired pneumonia; In hospitalized adults whose community-acquired pneumonia severity score is considered high; In immunocompromised patients, since multiplex PCR can identify a broad range of respiratory viruses; In hospitalized patients during a viral outbreak or in patients treated in intensive care. CONCLUSIONS: This tool will serve to support clinicians in their decision to use or not use multiplex PCR to detect respiratory viruses.
Authors' methods: A literature search was conducted in different databases for systematic reviews, meta-analyses, practice guidelines and primary studies. The grey literature was searched as well. In addition, experiential and contextual data were gathered from experts to ensure an understanding of the need to use this technology in clinical settings.
Project Status: Completed
Year Published: 2019
English language abstract: An English language summary is available
Publication Type: Other
Country: Canada
Province: Quebec
MeSH Terms
  • Multiplex Polymerase Chain Reaction
  • Respiratory Tract Infections
  • Virus Diseases
  • Nucleic Acid Amplification Techniques
  • Diagnosis
  • Nucleic acids
  • Viral diseases
Organisation Name: Institut national d'excellence en sante et en services sociaux
Contact Address: L'Institut national d'excellence en sante et en services sociaux (INESSS) , 2021, avenue Union, bureau 10.083, Montreal, Quebec, Canada, H3A 2S9;Tel: 1+514-873-2563, Fax: 1+514-873-1369
Contact Name: demande@inesss.qc.ca
Contact Email: demande@inesss.qc.ca
Copyright: Gouvernement du Québec
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.