Dual versus single chamber pacemaker therapy for atrioventricular block and sick sinus syndrome
Dretzke J, Lip G, Raftery J, Toff W, Fry-Smith A, Taylor R
Record ID 32002000721
English
Authors' objectives:
This report aims to assess the short- and long-term clinical and cost-effectiveness of dual versus single chamber pacemaker therapy for atrioventricular (AV) block and sick sinus syndrome.
Authors' recommendations:
The quality of the clinical effectiveness evidence was poor, and therefore the findings of this review are potentially subject to bias and overestimation of effect size. There was heterogeneity between studies in terms of population characteristics, outcomes measured and type of randomisation (mode or device), and the potential biases associated with this need to be taken into account. Nevertheless, a consistent benefit across studies of dual chamber pacing compared to single chamber pacing was observed for both primary and secondary outcomes. This included a statistically significant reduction in pooled mortality, pacemaker symptoms and exercise capacity. The effectiveness according to condition (sick sinus syndrome or atrioventricular block) could not be thoroughly investigated as the majority of patient data was represented in an aggregated form.
The clinical effectiveness findings support the current British Pacing and Electrophysiology Group guidelines that recommend dual chamber (over single chamber) pacing for AV block.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://www.birmingham.ac.uk/Documents/college-mds/haps/projects/WMHTAC/REPreports/2002/pacemaker.pdf
Year Published:
2002
URL for published report:
http://www.birmingham.ac.uk/research/activity/mds/projects/HaPS/PHEB/WMHTAC/REP/reports-list.aspx
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England
MeSH Terms
- Arrhythmias, Cardiac
- Heart Block
- Pacemaker, Artificial
- Sick Sinus Syndrome
Contact
Organisation Name:
West Midlands Health Technology Assessment Collaboration
Contact Address:
Elaena Donald-Lopez, West Midlands Health Technology Assessment Collaboration, Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT Tel: +44 121 414 7450; Fax: +44 121 414 7878
Contact Name:
louise.a.taylor@bham.ac.uk
Contact Email:
louise.a.taylor@bham.ac.uk
Copyright:
University of Birmingham
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.