The clinical effectiveness of trastuzumab for breast cancer: a systematic review
Lewis R, Bagnall A M, Forbes C, Shirran E, Duffy S, Kleijnen J, Riemsma R, ter Riet G
Record ID 32002000710
English
Authors' objectives:
The objective of the review was to evaluate the effectiveness of trastuzumab in the management of breast cancer.
Authors' recommendations:
Trastuzumab when used in combination with chemotherapy seemed to be more effective than chemotherapy alone for the treatment of MBC overexpressing HER2 at level 3+ in individuals who had not received prior treatment for metastatic breast cancer (MBC). However, it seemed to be assoqiated with congestive heart failure, particularly in patients that received anthracycline-based chemotherapy.
Trastuzumab monotherapy when used as second-line or subsequent therapy for the treatment of MBC overexpressing HER2 at level 3+ appeared to have some antitumour effects in terms of overall tumour response based on non-comparative studies (which provide relatively weak evidence) of moderate quality.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://www.hta.ac.uk/1252
Year Published:
2002
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Antineoplastic Agents
- Breast Neoplasms
- Neoplasm Metastasis
Contact
Organisation Name:
NIHR Health Technology Assessment programme
Contact Address:
NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name:
journals.library@nihr.ac.uk
Contact Email:
journals.library@nihr.ac.uk
Copyright:
2009 Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.