Procalcitonin point-of-care testing for initial assessment of suspected sepsis

Health Technology Wales
Record ID 32018000699
Authors' objectives: Health Technology Wales researchers searched for evidence on the clinical and cost effectiveness of point-of-care procalcitonin testing in the assessment and treatment of sepsis in children.
Authors' results and conclusions: The Health Technology Wales Assessment Group concluded that there is currently insufficient evidence about the outcomes of procalcitonin point-of-care testing (POCT) to inform production of guidance.
Authors' methods: The Evidence Appraisal Report is based on a literature search (strategy available on request) for published clinical and economic evidence on the health technology of interest. It is not a full systematic review but aims to identify the best available evidence on the health technology of interest. Researchers critically evaluate and synthesise this evidence. We include the following clinical evidence in order of priority: systematic reviews; randomised trials; non-randomised trials. We only include evidence for “lower priority” evidence where outcomes are not reported by a “higher priority” source. We also search for economic evaluations or original research that can form the basis of an assessment of costs/cost comparison. We carry out various levels of economic evaluation, according to the evidence that is available to inform this.
Authors' identified further reserach: Further studies are needed that assess the effectiveness of procalcitonin POCT, particularly with respect to whether its use can alter treatment choices in cases of suspected sepsis when compared to standard diagnostic pathways.
Project Status: Completed
Year Published: 2019
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Wales, United Kingdom
MeSH Terms
  • Point-of-Care Testing
  • Procalcitonin
  • Sepsis
  • Child
  • Emergency Medical Services
  • Procalcitonin
  • Point of Care Test
  • Emergency Care
  • Sepsis
Organisation Name: Health Technology Wales
Contact Address: Life Sciences Hub Wales 3 Assembly Square Cardiff CF10 4PL
Contact Name: Susan Myles, PhD
Contact Email:
Copyright: Health Technology Wales
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.