Pressurised intraperitoneal aerosol chemotherapy
Parsons, J, Ellery, B
Record ID 32018000693
English
Authors' results and conclusions:
Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is a new method of applying intraperitoneal chemotherapy as an aerosol. Early studies in patients with peritoneal metastases secondary to ovarian or other abdominal cancers have shown some efficacy; however it is difficult to assess the safety and effectiveness of PIPAC without comparative studies. There is only a relatively small pool of patients that this treatment has been used on so far, and even fewer of these have been reported on, as evidenced by the small studies featured in this Brief. As an experimental technique, it has been used in patients who are quite ill and have already failed multiple treatment regimes, but it may not be limited to that group of patients in the future.
Authors' recommendations:
HealthPACT noted that PIPAC may have significant advantages over existing chemotherapy techniques, which are painful and disabling, and associated with long length of stay and a high risk of adverse events. It was also noted that this technology is slowly diffusing into Australian clinical practice. HealthPACT does not support the introduction of this technology into clinical practice at this time, and recommends that PIPAC should only be conducted under the auspices of a clinical trial. Due to the potential benefits for patients, HealthPACT recommends a further review of the evidence on the use of PIPAC in 24 months.
Details
Project Status:
Completed
Year Published:
2015
URL for published report:
Not Available
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Aerosols
- Antineoplastic Agents
- Drug Delivery Systems
- Peritoneal Neoplasms
- Pressure
- Peritoneum
- Antineoplastic Combined Chemotherapy Protocols
Keywords
- pressurised intraperitoneal aerosol chemotherapy
Contact
Organisation Name:
Adelaide Health Technology Assessment
Contact Address:
School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617
Contact Name:
ahta@adelaide.edu.au
Contact Email:
ahta@adelaide.edu.au
Copyright:
Adelaide Health Technology Assessment (AHTA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.