PATHFAST Presepsin chemiluminescent enzyme immunoassay for the diagnosis and prognosis of sepsis
Ellery, B, Parsons, J
Record ID 32018000688
English
Authors' results and conclusions:
Sepsis is a severe and life-threatening complication of infection, and identifying it early may improve outcomes and save lives. As the gold-standard for diagnosing sepsis, blood culture, takes several days, many biomarkers are being investigated that can improve the speed at which sepsis can be diagnosed. Limited, low-level evidence on presepsin showed moderate diagnostic performance, with the caveat that it should not be used in isolation from other clinical factors to diagnose sepsis. No studies investigating the impact of presepsin result on treatment or outcomes were identified.
Authors' recommendations:
The PATHFAST Presepsin assay is one of many tests either developed, or in development, for the rapid detection of sepsis. There is insufficient evidence demonstrating the superiority of presepsin over tests such as procalcitonin. In addition, there is little evidence that demonstrates the use of presepsin results in changes in clinical behaviour when treating patients with suspected sepsis. HealthPACT does not support public investment in the PATHFAST Presepsin assay in clinical practice, and recommends no further research is warranted at this time.
Details
Project Status:
Completed
Year Published:
2016
URL for published report:
Not Available
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Sepsis
- Systemic Inflammatory Response Syndrome
- Bacterial Infections
- Luminescent Measurements
Keywords
- presepsin
- biological biomarkers
- chemiluminescent immunoassay
Contact
Organisation Name:
Adelaide Health Technology Assessment
Contact Address:
School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617
Contact Name:
ahta@adelaide.edu.au
Contact Email:
ahta@adelaide.edu.au
Copyright:
Adelaide Health Technology Assessment (AHTA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.