Processing and cryopreservation of ovarian tissue prior to or after gonadotoxic treatment to preserve fertility in females for the future
Milverton, J, Mittal, R, Carter, DA, Kessels, S, Newton, S, Schubert, C, Parsons, J, Merlin, T
Record ID 32018000652
English
Original Title:
Application 1435 Part B
Authors' results and conclusions:
Comparative safety - While the overall literature points to ovarian tissue cryopreservation (OTC) and ovarian tissue transplant (OTT) being relatively safe procedures, the evidence is weak and primarily found in case series. It should be noted that older patients wishing for children, and pre-pubertal patients requiring puberty induction, would need to go through both OTC and OTT and thereby increase their risk of adverse events. In comparison, patients undergoing oocyte cryopreservation would require only one invasive procedure requiring an anaesthetic for oocyte retrieval and one less invasive procedure for embryo transfer. However oocyte cryopreservation patients are at risk of hyperstimulation syndrome from taking hormonal stimulation therapy, whereas OTC/OTT patients are not. Comparative effectiveness - The literature search identified no evidence comparing OTC with oocyte cryopreservation or embryo cryopreservation. There is insufficient data to date to make any conclusion about the effectiveness of OTC and OTT for pregnancy, birth and induction of puberty for pre-pubertal patients. One systematic review of case series, provided data on pregnancies and birth in OTT patients. OTC followed by OTT appears to be successful in some women for achieving pregnancy and live birth with their own biological offspring. However, the evidence is not comparative, and therefore not high level evidence, and it remains a supposition (albeit plausible) that without the procedures many of these women would not have had children of their own. Therefore, it may be interpreted that the clinical claim is that greater access to OTC would result in superior rates of live births, increased quality of life, and improved relationships and family life.
Details
Project Status:
Completed
URL for project:
https://www.msac.gov.au/applications/1435-1
Year Published:
2018
URL for published report:
https://www.msac.gov.au/applications/1435-1
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Australia
MeSH Terms
- Cryopreservation
- Fertility
- Ovary
- Female
- Fertility Preservation
Contact
Organisation Name:
Adelaide Health Technology Assessment
Contact Address:
School of Public Health, Mail Drop 545, University of Adelaide, Adelaide SA 5005, AUSTRALIA, Tel: +61 8 8313 4617
Contact Name:
ahta@adelaide.edu.au
Contact Email:
ahta@adelaide.edu.au
Copyright:
<p>Adelaide Health Technology Assessment (AHTA) on behalf of NICS</p>
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