Children born from intracytoplasmic sperm injection
Tanbo T, Bakketeig L S, Jacobsen G, Orstavik K H, Lie R T, Lyngstadaas A
Record ID 32002000558
Norwegian
Authors' objectives:
This report aims to assess the available literature reporting the outcome of intracytoplasmic sperm injection (ICSI) pregnancies.
Authors' recommendations:
- There is a small increased risk of major birth defects in the offspring from treatment of severe male infertility with intracytoplasmic sperm injection. However, this increase is not significant.
- Available data do not indicate increased risk of any particular malformation.
- Whether ICSI treatment of infertile couples with normal karyotypes increases the occurence of chromosome abnormalities in the offsprings is currently not clarified.
- Sons of infertile males with Y chromosome microdeletions will inherit the same abnormality and therefore probably be infertile. Males with no known genetic cause for severely compromised sperm quality may also father sons with Y chromosome microdeletions.
- Theoretical models indicate that ICSI will not result in any substantial increase in male infertility.
- ICSI offspring do not seem to have any increase in neurological or psychomotor disabilities compared with offspring conceived by standard IVF treatment.
- Current data are inconclusive regarding pre- or postnatal growth disturbances
- It is not known whether the ICSI method per se, or factors related to the infertile couples, increase the risk of birth and other developmental defects. This systematic review demonstrates the need for more studies on the clinical outcomes of ICSI pregnancies.
Authors' methods:
Systematic review
Details
Project Status:
Completed
URL for project:
http://www.nokc.no/
Year Published:
2002
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Norway
MeSH Terms
- Infertility, Male
- Reproductive Techniques, Assisted
- Sperm Injections, Intracytoplasmic
Contact
Organisation Name:
Norwegian Institute of Public Health
Contact Address:
Universitetsgata 2, Postbox 7004 St. Olavs plass, NO-0310 Oslo NORWAY. Tel: +47 23 25 50 00; Fax: +47 23 25 50 10;
Contact Name:
Berit.Morland@nokc.no, dagny.fredheim@nokc.no
Contact Email:
Berit.Morland@nokc.no, dagny.fredheim@nokc.no
Copyright:
The Norwegian Knowledge Centre for the Health Services
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.