[Seroprevalence of Trypanosoma Cruzi infection in Latin American women of fertile age and during pregnancy in the Autonomous Community of the Basque Country]

Cisterna R, Liendo P, Ezpeleta G, Avila O, Basaras M
Record ID 32018000586
Spanish
Original Title: Seroprevalencia de la infección por Trypanosoma cruzi en mujeres latinoamericanas en edad fértil y en el embarazo en la Comunidad Autónoma del País Vasco
Authors' objectives: • Estimate the prevalence of Trypanosoma cruzi infection in women of fertile age from American trypanosomiasis-endemic zones, as well as the detection of parasite DNA, using the polymerase chain reaction. • Establish the correlation between the results obtained by using both of the aforementioned techniques (PCR and serology). • Determine from the results obtained whether Chagas disease complies with the necessary criteria for carrying out a global programme or by country due to the different prevalence. • Determine the epidemiology of the disease in our environment among Latin American women of fertile age.
Authors' results and conclusions: The prevalence of T. cruzi infection in immigrant Latin American women of fertile age was 18.89 % (51 confirmed cases using two techniques). This high prevalence can be explained in part by the composition of the sample studied, as in our population sample there is a high proportion of Bolivian women as they represent 54.8 % of the sample studied and are the women that have the highest prevalence of the disease in their source population. CONCLUSIONS AND RECOMMENDATIONS • Universal screening of all pregnant Latin American women at any stage of gestation and even at the moment of birth itself. • Identification of newborn children at risk (seropositive mother). • Treatment of the mother: following the breastfeeding stage. • Serological screening of previous children, establishing the appropriate treatment if the infection by the parasite is confirmed. • General information. As in other strategies implemented with the intention of preventing the transmission of pathogens, it is important to inform and create a sense of awareness both among those persons at risk and health professionals.
Authors' methods: Indirect diagnosis: two ELISA techniques (one with recombinant antigens) and IF. Direct diagnosis: realtime PCR with hydrolysis probe. Bibliographical search in MEDLINE Ovid of T. cruzi or Chagas disease with seroprevalence or antibodies and with PCR from 1980 to May, 2011.
Details
Project Status: Completed
Year Published: 2012
URL for published report: https://www.euskadi.eus/contenidos/informacion/2013_osteba_publicacion/es_def/adjuntos/D_13_02%20Seropreval_ACT.PDF
English language abstract: An English language summary is available
Publication Type: Other
Country: Spain
MeSH Terms
  • Trypanosoma cruzi
  • Chagas Disease
  • Seroepidemiologic Studies
  • Polymerase Chain Reaction
  • Infectious Disease Transmission, Vertical
  • Emigrants and Immigrants
  • Female
  • Infant, Newborn
  • Pregnancy Complications, Parasitic
Keywords
  • Trypanosoma cruzi
  • Chagas Disease
  • Seroepidemiologic Studies
  • Polymerase Chain Reaction
  • Reacción en Cadena de la Polimerasa
  • Estudios Seroepidemiológicos
  • Enfermedad de Chagas
Contact
Organisation Name: Basque Office for Health Technology Assessment
Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz
Contact Name: Lorea Galnares-Cordero
Contact Email: lgalnares@bioef.eus
Copyright: Osteba (Basque Office for Health Technology Assessment) Health Department of the Basque Government
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.