[Lipid metabolism disorders: review of the indications of fat free dietetic products and nutritional alternatives with regularly consumed foodstuffs]

Güemes I, Rico R, Zubizarreta A
Record ID 32018000581
Original Title: Trastornos del metabolismo de los lípidos: revisión de las indicaciones de los productos dietéticos libres de grasa y alternativas de nutrición con alimentos de consumo ordinario
Authors' objectives: The aim of this project is to determine the evidence concerning the safety and effectiveness of dietetic products indicated especially for lipid metabolism disorders, which in summarised form involve Low-fat Formulas and Fat-free Formulas.
Authors' results and conclusions: Forty-eight studies were selected from 121 identified studies. No studies were found on short chain fatty acid 3-hydroxyacyl-deshydrogenase deficiency. No studies were found on the use, safety and effectiveness of lipid free formulas (GSLI type) in the treatment of lipid metabolism disorders. The disorders studied are low prevalence, serious illnesses. This may be the reason why the studies identified and selected are of low methodological quality and are mainly studies of singles cases. For this reason, the results obtained must be read with extreme care. Conclusions The systematic review allows us to obtain an idea of the status of the research into the safety and effectiveness, which might be an aid to creating new lines of research. In prevalent and/or serious disorders it is necessary to promote appropriately-designed studies in order to obtain results that facilitate the adequate decision taking process of patients and health professionals. Until quality research papers have been developed, it is recommended to follow the proposals included in the protocols developed by clinical experts, accepted by the Services Profile groups of the National Health Service.
Authors' methods: Systematic review of the scientific literature: Definition of clinical questions in PICO format, design of the search strategy, selection criteria of studies in accordance with the components in the PICO questions, evaluation of their quality and the synthesis of the evidence in tables.
Project Status: Completed
Year Published: 2013
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Spain
MeSH Terms
  • Lipid Metabolism Disorders
  • Lymphangiectasis, Intestinal
  • Exocrine Pancreatic Insufficiency
  • Hypobetalipoproteinemias
  • Abetalipoproteinemia
  • Hypobetalipoproteinemia, Familial, Apolipoprotein B
  • Mitochondrial Myopathies
  • Apolipoprotein C-II
  • Carnitine O-Palmitoyltransferase
  • Acyltransferases
  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency
  • 3-Hydroxyacyl CoA Dehydrogenases
  • Electron-Transferring Flavoproteins
  • Smith-Lemli-Opitz Syndrome
  • Fat Substitutes
  • Diet, Fat-Restricted
  • Food, Fortified
  • Food, Formulated
  • Functional Food
  • Diet Therapy
  • Nutritional and Metabolic Diseases
  • Nutrition Therapy
  • Lipid Metabolism Disorders
  • Fat Restricted Diet
  • Diet Therapy
  • Nutritional and Metabolic Diseases
  • Nutrition Therapy
  • Terapia Nutricional
  • Enfermedades nutricionales y metabólicas
  • Dietoterapia
  • Dieta con Restricción de Grasas
  • Trastornos del Metabolismo de los Lípidos
Organisation Name: Basque Office for Health Technology Assessment
Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz
Contact Name: Lorea Galnares-Cordero
Contact Email: lgalnares@bioef.eus
Copyright: Osteba (Basque Office for Health Technology Assessment) Health Department of the Basque Government
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.