Original Title: Inyección intra-articular de plasma rico en plaquetas para el tratamiento de la artrosis de rodilla

Authors' objectives: 1. Assess the efficiency, effectiveness and safety of the treatment of knee OA by using the intra-articular injection of PRP. 2. Identify the regulations that currently control the use of PRP in Spain

Authors' results and conclusions: Those therapies known generically as “PRP” include very heterogeneous preparations both with respect to their composition, i.e., the concentration of platelets, the presence of leucocytes and exogenous platelet activation, which probably gives rise to different biological effects. It is convenient therefore to classify PRPs in accordance with their characteristics in order to reach a greater understanding of the effects deriving from their therapeutic use. In an attempt to unify as much as possible the interventions to be evaluated, these have been classified in accordance with their characteristics by using the classifications proposed by Mishra et al and DeLong et al (PAW classification system). An analysis of the evidence available from each type of PRP provides positive results in most studies, but there are few controlled studies and the number of patients studied for most types of PRP is very limited. Only in the case of 4B-type PRPs have 3 Randomized Clinical Trials been found that analyse the effects on patients with slight to moderate knee arthrosis. Even so, no detailed information is available regarding the effects of PRPs compared to placebos, about their effects and safety in the long term, or any comparison with the same kind of comparator in order to be able to make firm recommendations in this regard.

Authors' methods: A systematic review of the scientific literature has been carried out to identify the higher quality evidence available. Data from studies considered to be of low methodological quality have not been taken into consideration.

Project Status: Completed

Year Published: 2014

URL for published report: https://www.euskadi.eus/contenidos/informacion/2014_osteba_publicacion/es_def/adjuntos/Inyeccion%20Intra-articular.pdf

English language abstract: An English language summary is available

Publication Type: Rapid Review

Country: Spain

Organisation Name: Basque Office for Health Technology Assessment

Contact Address: C/ Donostia – San Sebastián, 1 (Edificio Lakua II, 4ª planta) 01010 Vitoria - Gasteiz

Contact Name: Lorea Galnares-Cordero

Contact Email: lgalnares@bioef.eus

Copyright: <p>Osteba (Basque Office for Health Technology Assessment) Health Department of the Basque Government</p>