Bioartificial liver. Systematic Review.
Moreno-Parejo JC, Llanos-Méndez A, Baños-Álvarez E, Isabel-Gómez R.
Record ID 32018000419
Spanish
Original Title:
Hígado bioartificial. Revisión Sistemática.
Authors' objectives:
The specific objectives are to assess the effectiveness and safety of bioartificial liver in terms of mortality, as well as in terms of clinical, haematological, biochemical or metabolic parameters and adverse effects, in patients with severe liver failure as definitive therapy or as a bridge to transplantation.
Authors' results and conclusions:
The studies analyzed in this review did not show conclusively that treatment of patients with severe liver failure with bioartificial liver is an effective intervention in terms of mortality or improvement of clinical, hemodynamic, metabolic and biochemical parameters, as compared to standard medical treatment. This fact is reinforced by the high quality and level of evidence from clinical trials retrieved. Furthermore, the absence of assessment of the quality of life of patients, did not permit evaluation of whether the improvement in the mortality found in the studies, although not significant, could justify intervention with bioartificial liver.
Details
Project Status:
Completed
Year Published:
2015
URL for published report:
https://www.aetsa.org/publicacion/higado-bioartificial-revision-sistematica/
English language abstract:
An English language summary is available
Publication Type:
Mini HTA
Country:
Spain
MeSH Terms
- Liver, Artificial
- Hepatic Insufficiency
- Liver Failure
- Acute-On-Chronic Liver Failure
- Liver Failure, Acute
Keywords
- Insuficiencia hepática
- Hígado artificial
Contact
Organisation Name:
Andalusian Health Technology Assessment Area
Contact Address:
Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309
Contact Name:
aetsa.csalud@juntadeandalucia.es
Contact Email:
aetsa.csalud@juntadeandalucia.es
Copyright:
Andalusian Health Technology Assessment Area(AETSA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.