The clinical effectiveness of tests to detect the presence of SARS-CoV-2 virus, and antibodies to SARS-CoV-2, to inform COVID-19 diagnosis

Health Technology Wales
Record ID 32018000398
English
Authors' objectives: This report aims to identify and summarise evidence that addresses the following questions: 1. What is the clinical effectiveness and/or economic impact of tests that detect the presence of the SARS-CoV-2 virus to inform COVID-19 diagnosis? 2. What is the clinical effectiveness and/or economic impact of tests that detect the presence of antibodies to the SARS-CoV-2 virus to inform diagnosis of COVID-19? This is a living evidence review and will be updated frequently as more evidence is published.
Authors' methods: Initial scoping-level evidence searches were conducted using databases, set up to aggregate COVID-19-specific evidence. Based on the results of these, we developed a specific search strategy to capture published evidence on SARS-CoV-2 diagnostics. We also hand-searched the sources included in the HTW COVID-19 Evidence Digest (https://www.healthtechnology.wales/covid-19/covid-19-evidence-digest/) for relevant evidence, and contacted key stakeholders in Wales for any published or unpublished data of relevance to this review. We followed the recommendations made in the Interim Guidance from the Cochrane Rapid Reviews Methods Group with regards to study selection, data extraction and evidence synthesis. (https://covidrapidreviews.cochrane.org/sites/covidrapidreviews.cochrane.org/files/public/uploads/cochrane_rr_-_guidance-23mar2020-final.pdf)
Details
Project Status: Completed
Year Published: 2020
English language abstract: An English language summary is available
Publication Type: Rapid Review
Country: Wales, United Kingdom
MeSH Terms
  • Coronavirus Infections
  • Enzyme-Linked Immunosorbent Assay
  • Nucleic Acid Amplification Techniques
  • Antibodies, Viral
  • Immunoassay
  • Microbial Sensitivity Tests
Keywords
  • COVID-19
  • SARS-CoV-2
  • Antibody Test
  • Virus Test
Contact
Organisation Name: Health Technology Wales
Contact Address: Life Sciences Hub Wales 3 Assembly Square Cardiff CF10 4PL
Contact Name: Susan Myles, PhD
Contact Email: healthtechnology@wales.nhs.uk
Copyright: Health Technology Wales
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.