Original Title: Evaluación de la eficacia, efectividad y seguridad de la ultrasonografía doppler transcraneal en pacientes con ictus isquémico agudo

Authors' objectives: To assess the efficacy, effectiveness and safety of TCD as adjunct of intravenous rt-PA in adults patients with acute ischaemic stroke.

Authors' results and conclusions: Evidence about efficacy TCD adjunct intravenous rt-PA when compared with intravenous rt-PA alone in adults with acute ischaemic stroke, in term of mortality, recovery and recanalization, was insufficient to be certain in outcomes. Evidence to comparative effectiveness of TCD adjunct intravenous rt-PA was not localized. There was discordance in safety outcomes of sonothrombolysis, (symptomatic intracerebral haemorrhage), varing between absence of effect and increase of intracerebral haemorrhage related to the intervention.

Authors' methods: A systematic review was carried out. A structured search was performed up to April 2016 in the electronic databases MEDLINE, EMBASE, SCI and PREMEDLINE. In addition, a hand search was conducted in the Cochrane collaboration, CRD, INAHTA, NICE, web sites of nationals and internationals agencies and units of health technology assessment included in INHATA and POP Database (EUnetHTA). E- mail alerts were set up from Medline (through Pubmed), with the aim of ensure that new papers are identified from the end of the bibliographic search to the publication of this report (December 2016). Furthermore, the exploration was completed with a cross search of references of includes studies. Two independent reviewers performed the selection of included studies, data extraction and risk of bias assessment. The reviewers resolved disagreements by discussion and consensus. The GRADE approach was used to grading the quality of evidence.

Project Status: Completed

Year Published: 2017

URL for published report: https://www.aetsa.org/publicacion/evaluacion-de-la-eficacia-efectividad-y-seguridad-de-la-ultrasonografia-doppler-transcraneal-en-pacientes-con-ictus-isquemico-agudo/

English language abstract: An English language summary is available

Publication Type: Mini HTA

Country: Spain

Organisation Name: Andalusian Health Technology Assessment Area

Contact Address: Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309

Contact Name: aetsa.csalud@juntadeandalucia.es

Contact Email: aetsa.csalud@juntadeandalucia.es

Copyright: AETSA, Andalusian Health Technology Assessment Area