Original Title: PET con 18F-FDG en el diagnóstico precoz de enfermedades degenerativas del sistema nervioso central.

Authors' objectives: To assess the clinical and analytical validity, safety and clinical utility of 18F-FDG PET in prodromal phase of Alzheimer's disease and his ability to predict the progression to dementia.

Authors' results and conclusions: • The evidence about clinical and analytical validity of 18F-FDG PET in patients in prodromal Alzheimer’s disease comes from a systematic review of high quality and five studies of moderate low quality. • The systematic review and prospective studies reported heterogeneity in results about clinical validity of 18F-FDG PET. • One study of high methodological quality but low statistical power reported results of poor clinical validity of 18F-FDG PET. Three studies of low quality reported discrepancies in results of clinical validity between studies in several technical of interpretation of PET scan. • The evidence about the analytical validity comes from one small study with 45 patients that showed a k value of 0.89. This evidence was insufficient to prove concordance in visual interpretation of images or concordance in software for automated interpretation. • Results about safety and effectiveness of 18F-FDG PET were not found, therefore, the clinical utility cannot be evaluated. • The localized evidence showed uncertainties about the use of PET 18F-FDG for diagnostic in prodromal Alzheimer’s disease or for differential diagnostic with others neurodegenerative diseases.

Authors' methods: A systematic review was carried out. A structured search was performed since February 2013 (the date of the last search from the systematic review identified in the initial search) up April 2016 in several electronic databases. Two independent reviewers performed the selection of included studies, data extraction and quality assessment. AMSTAR tool for systematic review and QUADAS-2 tool for prospective studies was used; disagreements were resolved by discussion and consensus.

Project Status: Completed

Year Published: 2018

URL for published report: https://www.aetsa.org/publicacion/pet-con-18f-fdg-en-el-diagnostico-precoz-de-enfermedades-degenerativas-del-sistema-nervioso-central/

Requestor: Health Ministry of Spain

English language abstract: An English language summary is available

Publication Type: Mini HTA

Country: Spain

Organisation Name: Andalusian Health Technology Assessment Area

Contact Address: Area de Evaluacion de Tecnologias Sanitarias Sanitarias de Andalucia (AETSA) Avda. Innovación, s/n Edificio Arena 1. Sevilla (Spain) Tel. +34 955 006 309

Contact Name: aetsa.csalud@juntadeandalucia.es

Contact Email: aetsa.csalud@juntadeandalucia.es

Copyright: AETSA, Andalusian Health Technology Assessment Area