Cervical Carcinoma Prevention - Implementation of an HPV screening test for early detection of cervical cancer in Austria

Fuchs E, Wolf S, Scrozynski G
Record ID 32018000366
German
Original Title: Zervixkarzinom Prävention – Implementierung eines HPV-Screening-Tests für die Früherkennung eines Gebärmutterhalskrebses bei Frauen in Österreich
Authors' objectives: For decades Cervical carcinoma used to be diagnosed by Pap testing (a morphological evaluation of stained cervical cells). Based on new scientific findings, which could establish a causal connection of the tumorigenesis with a persistent infection with human (high-risk) papillomaviruses, new test methods (based on the detection of these viruses in extracted cells of the cervix) were developed. Against this background, the aim of this report was to provide a basis for decision-making for the implementation of the HPV test in cervical carcinoma screening in Austria.
Authors' results and conclusions: For the implementation of the HPV test as a primary test (independent of whether as a singular test or as a co-test) in Austria, a transformation of the opportunistic screening into an organised screening programme would be necessary, including a precise definition of the target population and the screening interval. The biggest benefit for women, albeit with higher costs, is expected to be a primary test in an organised screening programme from 30 years of age and a 3-year screening interval.
Authors' methods: First, the international evidence on the efficacy and cost-effectiveness of HPV-based cervical cancer screening programs was summarised and an overview of recommendations in the European context was compiled. Furthermore, the existing cervical carcinoma screening strategy in Austria was examined and evaluated on the basis of the quality criteria of the European Guidelines for Cervical Cancer Screening. In addition, the organisational and logistical requirements for the implementation of an HPV test in cervical cancer screening in Austria were examined. A major chapter in the report addressed the budgetary impact of preselected cervical carcinoma screening strategies that incorporated a different form of HPV test.
Details
Project Status: Completed
URL for project: https://aihta.at/page/praevention-zervix-karzinom-implementierung-eines-hpv-screenings/en
Year Published: 2019
URL for published report: http://eprints.aihta.at/1223/1/HTA-Projektbericht_Nr.121.pdf
URL for additional information: http://eprints.aihta.at/1223/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Uterine Cervical Neoplasms
  • Human papillomavirus 6
  • Human papillomavirus 31
  • Human papillomavirus 18
  • Human papillomavirus 16
  • Human papillomavirus 11
  • Diagnostic Screening Programs
  • Mass Screening
  • Costs and Cost Analysis
  • Preventive Medicine
  • Austria
  • Women's Health
Keywords
  • Cervical cancer
  • human papillomavirus
  • screening
  • Budget-Impact Analysis
  • diagnostic test
Contact
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.