Allograft for anterior and posterior cruciate ligament reconstruction

Goetz G, De Villiers C
Record ID 32018000350
Authors' objectives: This report evaluated the effectiveness and safety of allograft cruciate ligament reconstruction compared to other cruciate ligament reconstruction technologies, e.g. autografts or conservative management in five indications. Evidence for effectiveness and safety comparing these allografts with autografts was found for three of the indications.
Authors' results and conclusions: In total, eight randomised controlled trials and one comparative cohort study met the eligibility criteria for the synthesis. The strength of evidence is very low to low. For Anterior Cruciate Ligament Reconstructions (ACLR), allografts may be comparable in terms of effectiveness but may be less safe due to potentially higher graft failures. For Posterior Cruciate Ligament Reconstructions (PCLR), effectiveness may be comparable yet there was insufficient evidence for the comparative safety. No evidence was found for the remaining two indications nor for comparing allografts with conservative management.
Authors' recomendations: The inclusion in the Austrian benefits catalogue is currently not recommended.
Project Status: Completed
Year Published: 2019
URL for published report:
URL for additional information:
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Allografts
  • Anterior Cruciate Ligament Reconstruction
  • Anterior Cruciate Ligament Injuries
  • Posterior Cruciate Ligament Reconstruction
  • Posterior Cruciate Ligament
  • Surgical Procedures, Operative
  • Transplantation
  • Allograft cruciate ligament reconstruction
  • autograft cruciate ligament reconstruction
  • ACLR
  • PCLR
  • graft failure
  • revision reconstruction
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name:
Contact Email:
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.