Osteochondral allograft transplantation for the knee (or other joints)

Vreugdenburg T, Rosian K, Vandepeer M, Stringer D
Record ID 32018000349
Authors' objectives: Defects in articular cartilage and subchondral bone can be caused by trauma, cancer, or other arthropathies. Fresh or delayed-fresh osteochondral allograft transplantation (OCA) is a technique used to repair (osteo)chondral defects. The procedure involves taking a core of the injured cartilage and underlying bone from the patient and replacing it with a size-matched transplant of mature hyaline cartilage and subchondral bone from a cadaver donor. The aim of our report was to evaluate the efficacy and safety of OCA for the treatment of (osteo)chondral defects, compared to other surgical management.
Authors' results and conclusions: One randomised controlled trial was identified, which investigated OCA to treat ankle defects. In addition, one case series investigating ankle defects, included for the assessment of safety only, and four case series investigating knee defects were identified. No relevant evidence was identified for other joints. The overall quality of the included evidence was low or very low for the reported outcomes.
Authors' recomendations: The current evidence is not sufficient to prove that OCA for the knee and other joints, for the treatment of osteochondral defects, is more effective and equally safe than other surgical procedures. Furthermore, the prospective single-arm studies had insufficient power to demonstrate treatment efficacy. The inclusion of OCA in the Austrian hospital benefit catalogue is therefore not recommended.
Project Status: Completed
Year Published: 2019
URL for published report: http://eprints.aihta.at/1204/1/DSD_115.pdf
URL for additional information: http://eprints.aihta.at/1204/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Allografts
  • Knee Joint
  • Joint Diseases
  • Therapeutics
  • Transplantation
  • Surgical Procedures, Operative
  • Joint pain
  • osteochondral defects
  • osteochondral allograft transplantation
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.