PET/PET-CT Evidence for need based planning in Germany and Austria

Fuchs S, Groessmann N, Eckhardt H, Busse R, Wild C
Record ID 32018000328
Original Title: PET/PET-CT Evidenz zum Bedarf und zur Planung in Deutschland und Österreich
Authors' objectives: Hardly any other medical technology has been evaluated as often in western countries as positron emission tomography (PET/PET-CT): this is an expression of uncertainty about the value of PET diagnostics in the care of patients. The present HTA report updates the evidence on oncological indications and adds neurological indications and inflammatory diseases to the LBI-HTA report of 2015. It was conducted in cooperation between the TU Berlin and the LBI-HTA to provide an updated decision support for evidence-based PET/PET-CT planning in Germany and Austria.
Authors' results and conclusions: In the area of oncology 5 HTAs, 188 positive and negative recommendations as well as additional information from 12 SR/MA was available. Comparing the results regarding oncological indications, a consensus was found in 8 indication areas where there was sufficient evidence for the respective sub-indication in favour of PET or PET-CT examinations. In contrast, regarding 8 indications (too) little evidence in favour of PET (individual decisions possible) was present. In a further 8 indications there was controversial and inconclusive evidence. Therefore, recommendations can only be made with reservations. With regard to neurological indications (2 HTAs, 28 recommendations & non-recommendations, 3 SR / MA), evidence was identified and presented for two sub-indication (Alzheimer's dementia or dementia as well as epilepsy). However, there was no agreement that there was sufficient evidence in favour of a PET / PET-CT scan for either of these two sub-indications. For inflammatory diseases statements from 3 HTAs, 18 recommendations and non-recommendations as well as additional information from 8 SR / MA could be identified. There was a consensus of sufficient evidence in favour of PET or PET-CT for infections of the vertebral column/spondylodiscitis. In a further 4 sub-indications there was controversial and inconclusive evidence present.
Authors' recomendations: Overall, the update 2018 resulted in more details and specifications compared to the LBI-HTA report of 2015. The overall recommendations for indications (and also detailed recommendations for sub-indications) as well as the explicit non-recommendations from the LBI-HTA report 2015 and this update of 2018 can serve as a needs-based and evidence-based decision support for PET/ PET-CT service provision in German and Austrian hospitals.
Authors' methods: For the present HTA report a systematic literature search and a targeted hand search were carried out. Thus, a total of 10 HTAs, 234 positive as well as negative recommendations and 23 additional systematic reviews/meta-analyses (SR/MA) could be identified.
Project Status: Completed
Year Published: 2018
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English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Positron-Emission Tomography
  • Positron Emission Tomography Computed Tomography
  • Health Planning
  • Diagnostic Imaging
  • Diagnostic Screening Programs
  • Medical Oncology
  • Neurology
  • PET
  • Positron Emissions Tomography
  • imaging
  • oncology
  • neurology
  • device planning
  • needs assessment
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
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This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.