Baroreceptor activation therapy for treatment-resistant hypertension

Hawlik K, Winkler R
Record ID 32018000323
Authors' objectives: Baroreceptor activation therapy (BAT) is proposed for patients with treatment-resistant hypertension (TRH), aiming at reducing blood pressure by electrically stimulating the carotid baroreflex.
Authors' results and conclusions: No comparative evidence was available for the second generation device. One case series (n=44) showed a reduction of the 24-hours blood pressure by 8mmHg with a follow-up of six months. The RCT on the first generation device did not show significant differences in the blood pressure reduction between the sham and the intervention group. No evidence on mortality, morbidity or quality of life as compared to standard treatment was available. The quality of evidence was very low.
Authors' recomendations: Given the current paucity of evidence, BAT can currently not be recommended for inclusion in the Austrian benefit catalogue.
Authors' methods: A systematic search in four databases yielded 416 records. Seven publications were included for the analysis and synthesis of the evidence: one RCT on the first generation device, one crossover trial and five observational before-after case series.
Project Status: Completed
Year Published: 2018
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URL for additional information:
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Therapeutics
  • Hypertension
  • Minimally Invasive Surgical Procedures
  • Surgical Procedures, Operative
  • Autonomic Nervous System
  • Baroreflex
  • Pressoreceptors
  • Treatment-resistant hypertension
  • baroreflex
  • baroreceptors
  • Baroreceptor Activation Therapy
  • renal denervation
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
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