Meniscal allograft transplantation for post-meniscectomy syndrome

Vreugdenburg T, Fischer S
Record ID 32018000322
Authors' objectives: Post-meniscectomy syndrome is broadly characterised by intractable pain following the partial or total removal of a meniscus. An new treatment approach is meniscal allograft transplantation (MAT), which involves the transplant of a cadaveric meniscal allograft into the knee of a patient who has had a prior (sub)total meniscectomy. The aim of our report was to evaluate the efficacy and safety of MAT for the treatment of post-meniscectomy syndrome, compared to conservative treatment.
Authors' results and conclusions: Overall, the level of evidence was very low. We could only identify one controlled trial, which showed superiority of MAT in some (but not all) outcomes compared to conservative treatment. In addition, we identified five case series to evaluate the safety. The complications rate in these case series was 0-38.5%.
Authors' recomendations: The inclusion of MAT in the Austrian hospital benefit catalogue is not recommended.
Project Status: Completed
Year Published: 2018
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English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Meniscus
  • Meniscectomy
  • Therapeutics
  • Tissue Transplantation
  • Knee Joint
  • Surgical Procedures, Operative
  • Allografts
  • Post-meniscectomy syndrome
  • knee pain
  • meniscal allograft transplantation
  • conservative treatment
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
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