(Percutaneous) left atrial appendage closure for the prevention of thromboembolic events in patients with atrial fibrillation. 3rd Update 2018

Semlitsch T, Krenn C
Record ID 32018000318
Original Title: (Perkutaner) Verschluss des linken Vorhofohres zur Thrombembolieprophylaxe bei PatientInnen mit Vorhofflimmern. 3. Update 2018
Authors' objectives: This report is the third update of a systematic review compiled in 2011 and evaluates the efficacy and safety of left atrial appendage closure (LAAC) either using percutaneous LAAC devices or a surgically implanted special clip compared to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation.
Authors' results and conclusions: The currently available evidence is not sufficient to prove that the percutaneous LAAC is as effective and as safe as OAC. Especially comparative studies on non-vitamin K oral anticoagulants (NOACs) are missing. For LAAC with the surgically implanted special clip, there is no evidence that allows an evaluation of efficacy and safety.
Authors' recommendations: At present, the inclusion into the Austrian hospital benefit catalogue is not recommended for both interventions. A re-evaluation is proposed in 2023.
Project Status: Completed
Year Published: 2018
URL for additional information: http://eprints.aihta.at/1168/
English language abstract: An English language summary is available
Publication Type: Full HTA
Country: Austria
MeSH Terms
  • Therapeutics
  • Surgical Procedures, Operative
  • Atrial Appendage
  • Atrial Function, Left
  • Atrial Fibrillation
  • Cardiovascular System
  • Stroke
  • Thromboembolism
  • Left atrial appendage
  • oral anticoagulation
  • atrial fibrillation
  • thromboembolism
  • stroke
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.