Authors' recommendations: Overall, durvalumab increases PFS, ORR, DOR, and TTDM in patients with stage III NSCLC, regardless of PD-L1 expression level prior to chemoradiation or histology, compared to placebo. However, overall survival (OS), quality of life (QoL) and long-term safety data are awaited, and study participants may not be representative of those in clinical practice. Direct comparison trials are lacking, to other immunotherapies (e.g. pembrolizumab), and cross-trial comparisons are cautioned due to differences in patient selection based on different PD-L1 assays. Further research is needed regarding the duration and timing of immunotherapy, the best regimen of chemoradiation for combination, and patient selection for greatest benefit based on predictive markers of efficacy and resistance.

Project Status: Completed

URL for project: https://hta.lbg.ac.at/page/horizon-scanning-in-der-onkologie/en

Year Published: 2017

URL for published report: http://eprints.hta.lbg.ac.at/1145/1/DSD_HSO_Nr.76.pdf

URL for additional information: http://eprints.hta.lbg.ac.at/1145/

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Austria

Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment

Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99

Contact Name: tarquin.mittermayr@aihta.at

Contact Email: office@aihta.at

Copyright: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)