Teduglutide (Gattex; Shire-NPS Pharmaceuticals Inc.) to reduce parenteral support requirements in adults with short bowel syndrome
HAYES, Inc
Record ID 32018000078
English
Authors' recommendations:
Health Problem:
Short bowel syndrome (SBS) is a rare malabsorptive condition in which the bowel is anatomically or functionally inadequate to meet absorptive nutritional needs. The goal of SBS therapy is to optimize enteral autonomy and reductions in parenteral support (PS) requirements, which is associated with morbidity, complications, reduced quality of life, and high cost.
Technology Description:
Teduglutide is a recombinant glucagon-like peptide (GLP-2) that is approved by the Food and Drug Administration for the treatment of adult patients with SBS who are dependent on PS. The once-daily dose of 0.05 milligram/kilogram is given subcutaneously in alternating sites in the abdomen or arms.
Controversy: One major controversy regarding teduglutide is the costeffectiveness of long-term teduglutide treatment of adult patients with SBS who are PS dependent. Additional controversies related to teduglutide administration include uncertainty regarding patient selection criteria, potential for use earlier (e.g., < 12 months post-start of intestinal failure) in the adaptation process, and its long-term safety, particularly with respect to malignancies and offteduglutide complications.
Key Questions:
Is teduglutide effective in reducing or eliminating PS requirements in adult patients with SBS? How does teduglutide therapy compare with other treatments for SBS? Is teduglutide therapy safe? Have definitive patient selection criteria been identified for teduglutide therapy in adults with SBS?
Details
Project Status:
Completed
Year Published:
2017
URL for published report:
The report may be purchased from:
http://www.hayesinc.com/hayes/crd/?crd=78686
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Adult
- Humans
- Parenteral Nutrition
- Peptides
- Pharmaceutical Preparations
- Short Bowel Syndrome
Contact
Organisation Name:
HAYES, Inc.
Contact Address:
157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
saleinfo@hayesinc.com
Contact Email:
saleinfo@hayesinc.com
Copyright:
Winifred S. Hayes, Inc
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.