Authors' recommendations: The publication date for this report is June 30, 2016. A typographical error was corrected on August 3, 2017. See Publication History in the full report for details. Description of Technology The MIST Therapy System is a noncontact, low-frequency ultrasound debridement device that promotes healing of chronic wounds by removing yellow slough, tissue exudates, fibrin, and bacteria from the wound surface. The main components of the MIST Therapy System are an ultrasound generator; a hand-held ultrasound transducer; and a single-use, disposable applicator with a bottle reservoir for sterile saline. The transducer tip vibrates 40,000 times per second to generate ultrasound waves at 40 kilohertz (kHz) that are carried to the wound via a saline mist. In addition to wound cleaning, ultrasonic energy has been proposed as a means of stimulating angiogenesis, growth factor production, and other cellular activities that contribute to wound healing. Patient Population The MIST Therapy System is indicated for promoting wound healing through wound cleansing and maintenance debridement by removing yellow slough, fibrin, tissue exudates, and bacteria. The MIST Therapy System may be considered for: deep tissue injuries, wounds not healing after 14 days, wounds requiring circulation stimulation, infected wounds, and for wounds with drainage. The focus of this report is on nonhealing venous leg ulcers. A companion Hayes Health Technology Brief focuses on lower extremity arterial wounds and diabetic foot ulcers. Clinical Alternatives Alternative debridement techniques include the use of saline-moistened dressings or hydrogels, surgical or sharp debridement, hydrosurgery, wet-to-dry dressings, enzymatic debridement, and maggot debridement therapy. Standard treatment for chronic wounds include sterile dressings, repositioning and pressure relief, topical antibiotics, and compression therapy. Alternative methods of wound treatment include electrical stimulation, pulsed electromagnetic induction, negativepressure wound therapy, hyperbaric oxygen, and high-frequency pulsed-current ultrasound. Surgical treatments such as skin flap reconstruction, sclerotherapy of a malfunctioning vein, or amputation of a digit or foot may be necessary if conservative treatments fail.

Project Status: Completed

Year Published: 2017

URL for published report: The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=46466

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: United States

Organisation Name: HAYES, Inc.

Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218

Contact Name: saleinfo@hayesinc.com

Contact Email: saleinfo@hayesinc.com

Copyright: Winifred S. Hayes, Inc