Single-dose intraoperative radiotherapy using Intrabeam® for early-stage breast cancer: an update
Almeida N, Dendukuri N.
Record ID 32017000416
English
Authors' objectives:
The objectives of this report were to update our previous report on the efficacy and safety of the Intrabeam® intraoperative device in preventing local breast cancer recurrences when compared with external beam radiotherapy, among women with early-stage breast cancer.
Authors' recommendations:
The TARGIT-A trial remains the sole trial comparing intraoperative radiation therapy using Intrabeam® to conventional external beam radiation therapy. Given the serious concerns with the results, the current evidence fails to conclusively establish the non-inferiority of Intrabeam® to external beam radiation.
The short median follow-up time of 2.4 years in the TARGIT-A trial is particularly problematic if hormone receptor-positive women, who constituted the majority of trial participants, are more likely to have recurrences later in follow-up.
A longer follow-up may indeed establish non-inferiority of Intrabeam®, but until such convincing evidence is available, Intrabeam® should only be considered an experimental procedure to be delivered under strict research protocols. Guidelines established by the radiation oncology societies as well as the selection criteria used in TARGIT-A may serve in selecting appropriate low-risk patients in such research settings.
Details
Project Status:
Completed
Year Published:
2015
URL for published report:
http://www.mcgill.ca/tau/files/tau/muhc_tau_2015_76_intrabeam_a.pdf
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
Canada
MeSH Terms
- Breast Neoplasms
- Humans
- Radiotherapy, Adjuvant
Contact
Organisation Name:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
Contact Address:
Technology Assessment Unit of the MUHC, Centre for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, 5252 boul. de Maisonneuve, Bureau 3F.50, Montreal, Quebec H4A 3S5
Contact Name:
nandini.dendukuri@mcgill.ca
Contact Email:
nandini.dendukuri@mcgill.ca
Copyright:
Technology Assessment Unit of the McGill University Health Centre (MUHC)
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