Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS

Hawlik K, Wild C
Record ID 32017000336
English
Authors' objectives: Extracorporeal cytokine adsorption therapy (ECAT) aims to reduce the cytokine concentration in the blood, thereby stabilising the overall immune response in sepsis and SIRS (Systemic Inflammatory Response Syndrome). We investigated the efficacy and safety of ECAT in its two main indications: to treat sepsis and to prevent SIRS during cardiopulmonary bypass surgery (CPB).
Authors' recommendations: Overall, three studies were identified that contained clinical data on ECAT. However, no data for the assessment of ECAT in patients with sepsis and septic shock were available. The overall quality of the studies on the preventive use during CPB was classified as very low. No conclusions could be drawn as to whether ECAT is a safe and effective intervention. We therefore do not recommend inclusion of ECAT in the Austrian BMG benefit catalogue and suggest a re-evaluation should randomised controlled trials in both indications become available.
Details
Project Status: Completed
URL for project: http://hta.lbg.ac.at/page/bewertung-medizinischer-einzelleistungen-mel-2017/en
Year Published: 2017
URL for published report: http://eprints.hta.lbg.ac.at/1129/1/DSD_106.pdf
URL for additional information: http://eprints.hta.lbg.ac.at/1129/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Austria
MeSH Terms
  • Cytokines
  • Hemadsorption
  • Humans
  • Sepsis
  • Systemic Inflammatory Response Syndrome
Contact
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
Copyright: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)
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