Percutaneous disc volume reduction with focus on chemonucleolysis. Update 2017

Semlitsch T, Posch N
Record ID 32017000333
German
Authors' objectives: This report is the first update of the systematic reviews "Chemonukleolyse und intradiskale Elektrotherapie" and "Perkutane Nukleotomie und perkutane Laserdiskusdekompression" compiled in 2009. The review investigates the efficacy and safety of the procedures, with particular focus on chemonucleolysis. These minimally invasive surgical procedures are used for the treatment of back pain and provide a treatment alternative to surgery.
Authors' recommendations: Current evidence suggests a benefit in efficacy for O2-O3-nucleolysis when compared to steroid injections alone with no difference regarding safety. In addition it appears to be equal in efficacy and safety compared to disc surgery. To date, there are no placebo-controlled trials available however. For chemonucleolysis with chymopapain and condoliase no recommendations were made, since these substances were either withdrawn from sale or have no current regulatory approval. For all other three interventions no significant new controlled studies have been identified since the previous reports in 2009.
Details
Project Status: Completed
URL for project: http://hta.lbg.ac.at/page/bewertung-medizinischer-einzelleistungen-mel-2017/en
Year Published: 2017
URL for published report: http://eprints.hta.lbg.ac.at/1126/1/DSD_21_Update2017.pdf
URL for additional information: http://eprints.hta.lbg.ac.at/1126/
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Austria
MeSH Terms
  • Chymopapain
  • Humans
  • Intervertebral Disc Chemolysis
  • Intervertebral Disc Displacement
Contact
Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment
Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99
Contact Name: tarquin.mittermayr@aihta.at
Contact Email: office@aihta.at
Copyright: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)
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