First- and second-generation antipsychotics in children and young adults: systematic review update

Pillay J, Boylan K, Carrey N, Newton A, Vandermeer B, Nuspl M, MacGregor T, Ahmed Jafri SH, Featherstone R, Hartling L
Record ID 32017000245
English
Authors' objectives: To review the evidence on first- and second-generation antipsychotics (FGAs and SGAs) for the treatment of various psychiatric and behavioral conditions in children, adolescents, and young adults (ages ≤ 24 years).
Authors' recommendations: SGAs probably improve to some extent key intermediate outcomes for which they are usually prescribed, but they have a poorer harms profile than placebo or no antipsychotic treatment, particularly for body composition and somnolence. Data for head-to-head comparisons within and between classes were generally limited and rated as insufficient or low strength of evidence. Evidence was sparse for patient-important outcomes (e.g., health-related quality of life) and outcomes for young children (<8 years). Key priorities for research are longterm comparative effectiveness and development of systems for monitoring harms.
Details
Project Status: Completed
Year Published: 2017
URL for published report: https://www.effectivehealthcare.ahrq.gov/ehc/products/615/2437/antipsychotics-children-update-report-170316.pdf
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: United States
MeSH Terms
  • Adult
  • Antipsychotic Agents
  • Child
  • Humans
  • Schizophrenia
  • Young Adult
Contact
Organisation Name: Agency for Healthcare Research and Quality
Contact Address: The Evidence-based Practice Center (EPC) Program, Center for Evidence and Practice Improvement, 5600 Fishers Lane, Rockville, MD 20857, USA. Tel: +1 301 427 1550
Contact Name: The EPC Program
Contact Email: epc@ahrq.hhs.gov
Copyright: Agency for Healthcare Research and Quality (AHRQ)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.