Authors' recommendations: Overall, even if the addition of ribociclib to letrozole increases the rate of toxicity significantly, there may be a benefit gained from adding it, since ribociclib increased the PFS rate by 11.9% and 20.8% (12-months vs. 18-months analysis). However, no evidence regarding the comparative OS advantage of ribociclib in combination with letrozole and no median PFS data were reported. Nevertheless, it might be crucial to investigate the impact of the treatment with CDK 4/6 inhibitors on the endocrine sensitivity of subsequent therapies. In addition, the effectiveness of ribociclib has not been supported by QoL outcomes. These and the lack of potential biomarkers highlight the necessity for further studies in order to identify those patients who would benefit the most from the treatment with ribociclib.

Project Status: Completed

URL for project: http://hta.lbg.ac.at/page/horizon-scanning-in-der-onkologie/en

Year Published: 2017

URL for published report: http://eprints.hta.lbg.ac.at/1115/1/DSD_HSO_Nr.65.pdf

URL for additional information: http://eprints.hta.lbg.ac.at/1115

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: Austria

Organisation Name: Ludwig Boltzmann Institute for Health Technology Assessment

Contact Address: Ludwig Boltzmann Institute for fuer Health Technology Assessment (LBI-HTA), Garnisongasse 7/rechte Stiege Mezzanin (Top 20), 1090 Vienna, Austria. Tel: +43 1 236 8119 - 0 Fax: +43 1 236 8119 - 99

Contact Name: tarquin.mittermayr@aihta.at

Contact Email: office@aihta.at

Copyright: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBI-HTA)