Ovarian tissue cryopreservation for preservation of fertility in patients undergoing gonadotoxic cancer treatment
HAYES, Inc
Record ID 32017000077
English
Authors' objectives:
Recent enhancements in the technology used for the treatment of cancer has greatly improved
survivorship rates in women with cancer. However, the cytotoxic effect of radiation and chemotherapy can result in premature ovarian failure (POF) and infertility.
Description of Technology: Ovarian tissue cryopreservation (OTC) involves harvesting and freezing ovarian tissue, thus preserving oocytes in primordial follicles located in the ovarian cortex. The ovarian tissue can
subsequently be autotransplanted into the cancer survivor after gonadotoxic treatment has ended and the patient is in remission. OTC eliminates the need for sperm donation and can be performed immediately without a delay in cancer treatment for ovarian stimulation. OTC may be offered to patients without a partner, prepubertal girls, and women who are not appropriate candidates for ovarian stimulation. Disadvantages of OTC include the invasive procedure that is required for ovarian tissue retrieval and the risk of reimplantation of neoplastic cells.
Patient Population: OTC is typically offered to patients < 35 years of age who are candidates for gonadotoxic therapy for the treatment of cancer and in whom the risk of POF is > 50% and they have a > 50% chance of
survival for at least 5 years. Reimplantation is indicated when there is a desire for conception, oncological treatment is completed, and remission from cancer is achieved.
Clinical Alternatives: Clinical alternatives to OTC include ovarian protection techniques of ovarian transposition
(oophoropexy), pelvic shielding, gonadotropin-releasing hormone analogs, and fractionated doses of chemotherapy and radiotherapy. Other alternatives include in vitro maturation, embryo cryopreservation, oocyte cryopreservation, utilization of an egg donor, and adoption.
Details
Project Status:
Completed
Year Published:
2016
URL for published report:
The report may be purchased from:
http://www.hayesinc.com/hayes/crd/?crd=55846
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
United States
MeSH Terms
- Humans
- Cryopreservation
- Fertility
- Neoplasms
Contact
Organisation Name:
HAYES, Inc.
Contact Address:
157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218
Contact Name:
saleinfo@hayesinc.com
Contact Email:
saleinfo@hayesinc.com
Copyright:
Winifred S. Hayes, Inc
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.