[A health technology evaluation study for reviewing possibility of data linkage]

Ko MJ, Park DW, Kim MS, Park CM, Kim YJ, Kang SH, Jo AJ, Tchoe HJ, Kim HJ, Choi JA, Lee WJ, Seo YS, Han CJ, Seo YS, Paik EK, Cho SS, Choi HJ
Record ID 32016001013
Korean
Authors' recomendations: This study linked data from various sources. However, there were difficulties owing to the stringent laws on the use of personal information. Therefore, it may be helpful to establish a legal basis to waive the informed consent process for individual subjects when conducting research for public benefit. Regarding the cardiovascular disease occurrence in type 2 diabetes patients treated with oral hypoglycemic agents, metformin use significantly reduced cardiovascular risk. In addition, in the context of secondary drugs, the TZD and DPP4 groups had significantly lower risks than the sulfonylurea group. The results of the present study form a foundation for a future large-scale randomized controlled clinical trial. Liver, pancreatic, colon, and rectal cancer patients with diabetes and on metformin (with high medication adherence) who underwent curative resection exhibited a lower all-cause mortality rate than other groups. In liver, colon, and rectal cancer, the relapse rates were lower with metformin use. These findings based on public data in Korea provide valuable epidemiological evidence of the anti-cancer effect of metformin, specifically by reducing mortality and relapse rates.
Details
Project Status: Completed
Year Published: 2016
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: South Korea
MeSH Terms
  • Humans
  • Information Storage and Retrieval
Contact
Organisation Name: National Evidence-based healthcare Collaborating Agency
Contact Address: National Evidence-based Healthcare Collaborating Agency (NECA), Changkyung B/D 9F, Wonnam-dong 28-7, Jongno-gu, Seoul, South Korea
Contact Name: hta_neca@neca.re.kr
Contact Email: hta_neca@neca.re.kr
Copyright: National Evidence-based Healthcare Collaborating Agency (NECA)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.