A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study

Simmons RK, Borch-Johnsen K, Lauritzen T, Rutten GEHM, Sandbaek A, Van den Donk M, Black JA, Tao L, Wilson ECF, Davies MJ, Khunti K, Sharp SJ, Wareham NJ, Griffin SJ
Record ID 32016000969
English
Authors' objectives: To quantify the cost-effectiveness of intensive multifactorial treatment of screen-detected diabetes. Intensive treatment (IT) of cardiovascular risk factors can halve mortality among people with established type 2 diabetes but the effects of treatment earlier in the disease trajectory are uncertain.
Authors' recommendations: Compared with RC, IT was associated with modest increases in prescribed treatment, reduced levels of risk factors and non-significant reductions in cardiovascular events, microvascular complications and death over 5 years. IT did not adversely affect patient-reported outcomes. IT was not cost-effective but might be if delivered at a reduced cost. The lower than expected event rate, heterogeneity of intervention delivery between centres and improvements in general practice diabetes care limited the achievable differences in treatment between groups. Further follow-up to assess the legacy effects of early IT is warranted.
Details
Project Status: Completed
URL for project: http://www.nets.nihr.ac.uk/projects/hta/08116300
Year Published: 2016
URL for published report: http://www.journalslibrary.nihr.ac.uk/hta/hta20640/#/abstract
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: England, United Kingdom
MeSH Terms
  • Humans
  • Cost-Benefit Analysis
  • Diabetes Mellitus, Type 2
  • Mass Screening
  • Primary Health Care
  • Secondary Prevention
Contact
Organisation Name: NIHR Health Technology Assessment programme
Contact Address: NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK
Contact Name: journals.library@nihr.ac.uk
Contact Email: journals.library@nihr.ac.uk
Copyright: Queen's Printer and Controller of HMSO
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.