Authors' recommendations: Description of Technology: Concentrated bone marrow aspirate (CBMA) is produced from native bone marrow aspirate (BMA), usually obtained from the iliac crest or local vertebrae. An aspiration probe or needle is inserted into bone under the guidance of fluoroscopy to obtain a sufficient quantity of BMA for a planned procedure. The BMA is then processed, often filtered first, and then centrifuged, to concentrate its contents. CBMA contains mononuclear cells such as mesenchymal stem cells (MSCs), hematopoietic stem cells, B cells, T cells, monocytes, and growth factors (regulating proteins). The MSCs can differentiate into a variety of cell types, including osteoblasts, while various BMA growth factors can stimulate additional bone growth. The quality of the CBMA may vary according to a number of factors, including the health and age of a patient and the aspiration and concentration techniques; these can affect the amount of osteoinductive and osteogenic cells and constituents in CBMA, and perhaps the success of their use in spinal fusion. Patient Population: CBMA is indicated in adult or pediatric patients undergoing spinal surgery who do not have a contraindication to the collection and use of CBMA.

Project Status: Completed

Year Published: 2016

URL for published report: The report may be purchased from: http://www.hayesinc.com/hayes/crd/?crd=39626

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: United States

Organisation Name: HAYES, Inc.

Contact Address: 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218

Contact Name: saleinfo@hayesinc.com

Contact Email: saleinfo@hayesinc.com

Copyright: 2014 Winifred S. Hayes, Inc