Vertebral augmentation involving vertebroplasty or kyphoplasty for cancer-related vertebral compression fractures: OHTAC recommendation

Health Quality Ontario
Record ID 32016000759
Authors' recommendations: Clinical Findings - Vertebral augmentation is associated with a clinically significant reduction in pain, with subsequent decreases in opioid use, improved physical functional disability scores, reduced disability, and improved quality of life. - These improvements were reported for both vertebroplasty and kyphoplasty and for a diverse group of cancer patients with mixed primary spinal metastatic cancers, multiple myeloma, or hemangiomas. - The most common adverse event after vertebral augmentation was bone cement leakage, which was usually asymptomatic. Major adverse events following vertebral augmentation rarely occurred. Economic Findings - The cost per case for kyphoplasty and vertebroplasty was $7,246 and $3,870, respectively. Compared with non-surgical management, kyphoplasty and vertebroplasty were associated with incremental cost-effectiveness ratios of $33,471 and $17,870, respectively, per quality-adjusted life-year. - We estimated that the current use of vertebral augmentation procedures cost the Ministry of Health and Long-Term Care about $2.5 million in fiscal year 2014/15 and that more widespread use of these procedures would result in an incremental cost of approximately $67,302 to $913,386, depending on the scenario considered. The Ontario Health Technology Advisory Committee accepted the findings of the health technology assessment. Given the substantial clinical benefit and the favourable incremental cost-effectiveness ratio OHTAC decided to recommend in favour of public funding.
Project Status: Completed
Year Published: 2016
English language abstract: An English language summary is available
Publication Type: Not Assigned
Country: Canada
MeSH Terms
  • Humans
  • Fractures, Compression
  • Kyphoplasty
  • Neoplasms
  • Spinal Fractures
  • Spine
  • Vertebroplasty
Organisation Name: Health Quality Ontario
Contact Address: Evidence Development and Standards, Health Quality Ontario, 130 Bloor Street West, 10th floor, Toronto, Ontario Canada M5S 1N5
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Copyright: Health Quality Ontario (HQO)
This is a bibliographic record of a published health technology assessment from a member of INAHTA or other HTA producer. No evaluation of the quality of this assessment has been made for the HTA database.