Authors' recommendations: Heart failure is a common and disabling condition that affects the heart's ability to pump blood around the body. It is often caused by coronary heart disease (ischaemic heart disease), which happens when there is a build-up of fatty deposits in the blood vessels of the heart. These fatty deposits mean the heart muscle does not receive enough oxygen to work properly or they may completely block off a blood vessel leading to a heart attack (myocardial infarction), where a section of heart muscle dies completely. Current treatments for heart failure aim to improve the symptoms of heart failure, improve the heart's pumping action, and prevent further myocardial infarctions. C3BS-CQR-1 is a new type of treatment that aims to repair and regenerate heart muscle. It is produced from the patient's own bone marrow cells and is injected directly into the damaged areas of heart muscle. It is currently being studied to see whether it improves the symptoms of heart failure and reduces the chance that a patient dies from their disease. If C3BS-CQR-1 is licensed for use in the UK, it could offer a completely new treatment option that has the potential to repair damaged heart muscle in patients with heart failure.

Project Status: Completed

Year Published: 2016

URL for published report: http://www.hsric.nihr.ac.uk/topics/c3bs-cqr-1-c-cure-for-heart-failure-secondary-to-ischaemic-cardiomyopathy/

English language abstract: An English language summary is available

Publication Type: Not Assigned

Country: England, United Kingdom

Organisation Name: NIHR Horizon Scanning Centre

Contact Address: The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom. Tel: +44 121 414 7831, Fax: +44 121 2269

Contact Name: c.packer@bham.ac.uk

Contact Email: c.packer@bham.ac.uk

Copyright: NIHR Horizon Scanning Research&Intelligence Centre (NIHR HSRIC)