Heartcel for heart failure in patients at risk of incomplete revascularisation following coronary artery bypass graft
NIHR HSRIC
Record ID 32016000634
English
Authors' objectives:
Heart failure is a common and disabling condition that affects the heart's ability to pump blood around the body. It is often caused by coronary artery disease, which happens when there is a build-up of fatty deposits in the blood vessels of the heart. These fatty deposits mean the heart muscle doesn't receive enough oxygen to work properly or they may completely block off a blood vessel leading to a heart attack (myocardial infarction), where a section of heart muscle dies completely forming a scar. Patients with heart failure may be treated with surgery in an operation called a coronary artery bypass graft, which improves blood flow to the heart muscle.
Heartcel is a stem cell therapy given as an injection into the heart muscle during a coronary artery bypass graft. Some studies have suggested that Heartcel may be helpful in improving the function of the heart following this surgery by regenerating the scar tissue associated with heart failure.
If Heartcel is licensed for use in the UK, it could be a new treatment option for patients undergoing coronary artery bypass graft surgery who are at high risk for it not managing to improve blood flow. Heartcel has the potential to reduce symptoms of heart failure and increase survival in this small group of patients.
Details
Project Status:
Completed
Year Published:
2016
URL for published report:
http://www.hsric.nihr.ac.uk/topics/heartcel-for-heart-failure-in-patients-at-risk-of-incomplete-revascularisation-following-coronary-artery-bypass-graft/
English language abstract:
An English language summary is available
Publication Type:
Not Assigned
Country:
England, United Kingdom
MeSH Terms
- Humans
- Coronary Artery Bypass
- Heart Failure
Contact
Organisation Name:
NIHR Horizon Scanning Centre
Contact Address:
The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health and Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom. Tel: +44 121 414 7831, Fax: +44 121 2269
Contact Name:
c.packer@bham.ac.uk
Contact Email:
c.packer@bham.ac.uk
Copyright:
NIHR Horizon Scanning Research&Intelligence Centre (NIHR HSRIC)
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